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  • C.M. Guardia, E. Kane, A.G. Tebo, A. Sanders, D. Kaya, and K.E. Grogan^. The power of peer networking for improving STEM faculty job applications: a successful pilot program. Proc. R. Soc. B 209:20230124 (link).​​​


  • M. Ishida, M.G. Otero, C. Freeman, P.A. Sánchez-Lara, C.M. Guardia, T.M. Pierson^ & J.S. Bonifacino^. A neurodevelopmental disorder associated with an activating de novo missense variant in ARF1. Hum Mol Genet. ddac279 (link)

  • G. Hu*, P.J. Hauk*, N. Zhang, W. Elsegeiny, C.M. Guardia, A. Kullas, K. Crosby, R.R. Deterding, M. Schedel, P. Reynolds, J.K. Abbott, V. Knight, S. Pittaluga, M. Raffeld, S.D. Rosenzweig, J.S. Bonifacino, G. Uzel, P.R. Williamson^, and E.W. Gelfand. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A. Autophagy (link).

  • C.D. Williamson, C.M. Guardia, R. De Pace, J.S. Bonifacino, and A. Saric^. Measurement of lysosome positioning by shell analysis and line scan. Methods Mol Biol. 2473:285-306 (link).

  • T. Ahmad, D. Vullhorst, R. Chaudhuri, C.M. Guardia, N. Chaudhary, I. Karavanova, J.S. Bonifacino & A. Buonanno^. Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3. J Cell Biol. 221(7):e202110167 (link)​​​


  •  E. Mailler, C.M. Guardia, X. Bai, M. Jarnik, C.D. Williamson, Y. Li, N. Maio, A. Golden, & J.S. Bonifacino^. The autophagy protein ATG9A enables lipid mobilization from lipid dropletsNat Commun. 12, 6750 (link)

  • C.M. Guardia, E. Kane, A.G. Tebo, A. Sanders, D. Kaya, & K.E. Grogan^. The power of peer networking for improving faculty job applications: a successful pilot program. Submitted (BioRXiv - DOI: 10.1101/2021.10.16.464662)

  • J.L. Nieto-Torres*^, J. Durgan*, A. Franco-Romero*, P. Grumati*, C.M. Guardia*, A.M. Leidal*, M.A. Mandell*, C.G. Towers*, & F. Wang*. The Autophagy, Inflammation and Metabolism Center international eSymposium – an early-career investigators’ seminar series during the COVID-19 pandemic. J Cell Sci 134 (19): jcs259268 (link)

  • C.M. Guardia^, A. Hierro, & D.C. Gershlick^. Editorial: Energy Requirements in Membrane Trafficking. Front Cell Dev Biol. 9:750633 (link)

  • A. Saric, S. Freeman, C.D. Williamson, M. Jarnik, C.M. Guardia, M. Fernandopulle, D.C. Gershlick, & J.S. Bonifacino^. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun. 12, 4552 (link)

  • C.M. Guardia, A. Jain, R. Mattera, A. Friefeld, Y. Li, & J.S. Bonifacino^. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell. mbcE21060295 (link)

  • A.D. Senol*, M. Samarani*, S. Syan, C.M. Guardia, T. Nonaka, N. Liv, P.L. Lambert, M. Hasegawa, J. Klumperman, J.S. Bonifacino, & C. Zurzolo^. α-Syn fibrils affect lysosome structure & function to propagate misfolding through TNTs. PLoS Biol 19(7): e3001287 (link)


  • C.M. Guardia*, E.T. Christenson*, W. Zhou, X. Tan, T. Lian, J.D. Faraldo-Gómez, J.S. Bonifacino, J. Jiang & A. Banerjee^. The structure of human ATG9A and its interplay with the lipid bilayer. Autophagy DOI: 10.1080/15548627.2020.1830522

  • C.M. Guardia*, X. Tan*, T. Lian*, M.S. Rana*, W. Zhou, E.T. Christenson, A.J. Lowry, J.D. Faraldo-Gómez, J.S. Bonifacino^, J. Jiang^, & A. Banerjee^. Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery. Cell Reports 31(13), 107837 (link)


Our cryo-EM structure of human ATG9A


  • C.M. Guardia, R. DePace, A. Sen, A. Saric, D.A. Kolin, A. Kunwar, & J.S. Bonifacino^. Reversible association with motor proteins (RAMP): a streptavidin-based dimerization method to manipulate organelle positioning. PLoS Biol. 17(5): e3000279. (link)

  • S. Gaurav*, C.M. Guardia*, A. Roy, A. Vassilev, A. Saric, L.N. Griner, J. Marugan, J. Marugan, M. Ferrer, J.S. Bonifacino, & M.L. DePamphilis^. A family of PIKfyve inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupts multiple events in lysosome homeostasis. Autophagy, 26:1-25. (link)

RAMP_crazy MT looped.gif

Manipulating organelles
inside the cell with RAMP


  • C.M. Guardia, R. DePace, R. Mattera, & J.S. Bonifacino^. (Review). Neuronal functions of adaptor complexes involved in protein sorting. Curr Opin Neurobiol, 51, 103-10. (link)


  • R. Mattera*, S. Yoon Park*, R. DePace, C.M. Guardia, & J.S. Bonifacino^. AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation. PNAS, 114(50), E10697-706. (link)

  • R. Jia, C.M. Guardia, J. Pu, Y. Chen & J.S. Bonifacino^. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy, 13(10):1648-63. (link)

  • G.G. Farías, C.M. Guardia, R. De Pace, D.J. Britt & J.S. Bonifacino^. BORC/Kinesin-1 ensemble drives polarized transport of lysosomes into the axon. PNAS, 114(14), E2955-64. (link)


  • J. Pu, C.M. Guardia, T. Keren-Kaplan & J.S. Bonifacino^. (Review). Mechanisms and functions of lysosome positioning. Journal of Cell Science, 0, 1-11. (link)

  • C.M. Guardia, G.G. Farías, J. Pu, R. Jia & J.S. Bonifacino^. BORC functions upstream of kinesins 1 and 3 to regulate regional movement of lysosomes along different microtubule tracks. Cell Reports, 17(8), 1950-61. (link)

  • D.J. Britt, G.G. Farías, C.M. Guardia, & J.S. Bonifacino^. (Review). Mechanisms of polarized organelle distribution in neurons. Front. Cell Neurosci. 10(88), 7842-57. (link)


Lysosomes moving and stretching
inside the cell with the help of kinesins


  • G.G. Farías, C.M. Guardia, D.J. Britt, X. Guo, & J.S. Bonifacino^. Sorting of dendritic and axonal vesicles at the pre-axonal exclusion zone. Cell Reports 13(6), 1221-32. (link)

  • R. Mattera, C.M. Guardia, S.S. Sidhu & J.S. Bonifacino^. Bivalent motif-ear interactions mediate the association of the accessory protein tepsin with the AP-4 adaptor complex. J. Biol. Chem. 290(52), 30736-49. (link)


  • C.M. Guardia, J.J. Caramelo, M. Trujillo, S.P. M-Huergo, R. Radi, D.A. Estrin & G.A. Rabinovich^. Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology 24(5), 428-41. (link)

  • A. Zeida, C.M. Guardia, P. Lichtig, L.L. Perissinotti, L.A. Defelipe, A. Turjanski, R. Radi, M. Trujillo & D.A. Estrin^. (Review). Thiol redox biochemistry: insights from computer simulations. Biophysical Reviews 1(6), 27-46. (link)


  • S. Di Lella, V. Sundblad, J.P. Cerliani, C.M. Guardia, D.A. Estrin, G.R. Vasta & G.A. Rabinovich^. (Review). When galectins recognize glycans: from biochemistry to physiology and back again. Biochemistry 50(37), 7842-57. (link)

  • C.M.A. Guardia, D. Gauto, S. Di Lella, G. Rabinovich, M.A. Martí & D.A. Estrin^. An integrated computational analysis of structure, dynamics and ligand binding interaction of the human galectin network. J. Chem. Inf. Model. 51(8), 1918-30. Cover of the Issue (link)


  • S. Di Lella, M.A. Marti, D. Croci, C.M.A. Guardia, J. Diaz Ricci, G.A. Rabinovich, J.J. Caramelo & D.A. Estrin^. Linking structure and thermal stability of the beta-galactosidase binding protein galectin-1 to ligand binding and dimerization equilibria. Biochemistry 49(35), 7652-58. (link)


  • D.F. Gauto, S. Di Lella, C.M.A. Guardia, D.A. Estrin & M.A. Martí^. Carbohydrate-binding proteins: dissecting ligand structures through solvent environment occupancy. J. Phys. Chem. B 113(25): 8717-24. (link)


  • C.M.A. Guardia, M.C. González Lebrero, S.E. Bari & D.A. Estrin^. QM/MM investigation of the reaction products between nitroxyl and O2 in aqueous solution. Chem. Phys. Lett. 463, 112-16. (link)

* denotes equal contribution

^ denotes corresponding authors

More information is available at Google Scholar

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